1. A single assay that detects all 4 classes of genomic alterations required to comprehensively profile a tumor.
2. Identification of resistance mutations or fusions in lung cancer, often missed by other ctDNA assays^§
3. Can be integrated with FoundationOne results to give a more complete picture of the evolution of a patient’s tumor
4. Requires only two 10mL tubes of blood

^{†>99% PPV for all alterations, calculated as a weighted average of the PPV for each class of alteration, with the weighting based upon the frequency with which each class is detected. The PPV for base substitutions, indels, rearrangements, and copy number variations, each independently, are 99.9%, 98.8%, 98.0%, and 97.6%, respectively.}

^{‡ >99% sensitivity for base substitutions, indels, and rearrangements at ≥ 1% MAF. Sensitivity for base substitutions at >0.5% MAF is 98.9% and sensitivity for copy number variations is >95% when the tumor fraction is ≥ 20%.}