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Brian Alexander, MD, MPH

Chief Medical Officer


Dr. Brian Alexander was named Chief Medical Officer of Foundation Medicine in April 2019. Since joining the company in September 2018 as a senior vice president of clinical development, Brian has driven the clinical development team’s focus on advancing care for cancer patients by leveraging molecular information to help improve clinical decision-making and therapeutic development.

In addition to his role at Foundation Medicine, Dr. Alexander is a physician, as well as an Associate Professor of Radiation Oncology at Harvard Medical School and Dana-Farber/Brigham and Women’s Cancer Center. He founded the Program in Regulatory Science at the Dana-Farber Cancer Institute and is a Member of the Scientific Council of the Harvard/MIT Center for Regulatory Science.

Dr. Alexander is also President and co-founder of the Global Coalition for Adaptive Research, an organization focused on accelerating the discovery and development of cures for patients with rare and deadly diseases.

Dr. Alexander’s research interests focus on innovations in clinical evidence generation to support the development of therapeutics, biomarkers, and novel endpoints. Dr. Alexander co-authored a book titled “Diagnostic Test Interpretation and Reasoning Under Uncertainty,” detailing the use of Bayesian approaches to clinical decision-making and is the recipient of the Burroughs-Wellcome Innovations in Regulatory Science Award for his work applying such approaches to clinical trial design. Dr. Alexander was the founding principal investigator of INSIGhT, a multi-institutional genomic biomarker-based Bayesian adaptively randomized trial for patients with glioblastoma.

Prior to his faculty appointment at Harvard Medical School, Dr. Alexander served as a White House fellow and Special Assistant to the Secretary of Veterans Affairs. In that role, he helped prepare the VA for the transition of administrations, worked to develop a public reporting system for quality, and served as a health policy advisor to the Secretary. Dr. Alexander organized the standup of the VA’s Coordinating Council on National Health Reform and directed the activities of its multi-team Health Reform Working Group. He was also a member of the Institute of Medicine’s Committee on the Governance and Financing of Graduate Medical Education.

Dr. Alexander received his B.A. from Kalamazoo College, M.D. from the University of Michigan Medical School, and M.P.H. from the Harvard School of Public Health. He completed his training in radiation oncology at the Harvard Radiation Oncology Program.