Foundation Medicine Launches Gene Expression Profiling Program to Identify Known and Novel Biomarkers in Advanced Cancer
“In order to maximize the potential of personalized cancer therapy, we need a comprehensive biomarker strategy that includes not only tumor mutational changes and signatures but robust readouts of gene expression, requiring deep expertise in next generation DNA and RNA sequencing,” said
CGP of individual tumors is critical to advancing precision oncology. Through its suite of CGP assays,
Building on Foundation Medicine’s existing DNA and RNA sequencing platforms, GEP has the potential to provide insights into gene expression signatures that may serve as predictive biomarkers of immunotherapy response. For example, measuring expression of genes tied to tumor-infiltrating lymphocytes, T-cell proliferation, and T-cell receptor diversity have all been associated with response to different types of oncology treatments. Under this program,
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Cautionary Note Regarding Forward-Looking Statements for
This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding the ability of gene expression profiling to identify novel genomic and expression-based biomarkers of response; the ability of CGP to advance prevision oncology or improve patient outcomes; and the benefits of Foundation Medicine’s gene expression profiling program to biopharma partners, including optimizing clinical research development programs and drug development. All such forward-looking statements are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include the risk that the gene expression profiling program does not proceed or does not meet its objectives; gene expression profiling is not an effective method of identifying genomic and expression-based biomarkers; the utility of gene expression profiling for biopharma partners does not materialize; and the risks described under the caption "Risk Factors" in
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Foundation Medicine, Inc.
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Lee-Ann Murphy, 617-245-3077
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Kimberly Brown, 617-418-2215
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