• Identification of an EML4-ALK rearrangement reveals optimal new treatment for lung cancer

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    • Identification of a PIK3CA mutation explains targeted therapy resistance and offers a new clinical trial option for lung cancer

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    • KRAS mutation indicates colorectal cancer is unlikely to respond to available therapies, but suggests an alternative therapeutic strategy

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    • Rebiopsy reveals valuable new genomic information for treating gastrointestinal stromal tumor (GIST)

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    • Genomic subtyping opens a clinical trial option for metastatic endometrial cancer

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    • BRAF mutation in melanoma opens an option for targeted initial therapy

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