Foundation Medicine Identifies Novel, Clinically Actionable Gene Fusion NTRK1 in Lung Cancer; Data Published in Nature Medicine
"Our understanding of cancer complexity is increasing, and lung cancer continues to be dissected into a series of uncommon or even rare diseases based on the molecular alterations driving a patient's individual cancer," stated
In an effort to identify additional potential oncogenes in lung cancer,
"Following the recent publication of our analytic validation study of FoundationOne, the identification of NTRK1 further supports the clinical utility of comprehensive next-generation sequencing as a method to discover novel drug sensitive genomic alterations that would not otherwise be tested for or identified using currently available diagnostic approaches," commented
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Cautionary Note Regarding Forward-Looking Statements
This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding new and potentially clinically actionable gene fusions, the development of new treatment options for patients with certain gene fusions, the evolution of FoundationOneTM, and the clinical utility of FoundationOneTM and next-generation sequencing as a method to discover novel drug sensitive genomic alterations. All such forward-looking statements are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include the risks that FoundationOneTM and any subsequent products may never achieve significant commercial adoption or reimbursement support;
1. Vaishnavi, A. et al. Oncogenic and drug sensitive NTRK1 rearrangements in lung cancer. Nature Medicine, 2013. DOI: 10.1038/nm.3352.
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3. Frampton, G.M. et al. Validation and clinical application of a cancer genomic profiling test using next-generation sequencing. Nature Biotechnology, 2013; DOI: 10.1038/NBT.2696.
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